摘要
目的:探讨P16、Cyclin D1在外阴鳞癌发生、发展中的作用。方法:采用免疫组化SABC法,检测32例外阴鳞状上皮增生、32例VIN、34例外阴鳞癌组织标本中P16、Cyclin D1的表达。结果:与正常皮肤及外阴鳞状上皮增生相比,VIN组织中P16的阳性率降低,Cyclin D1的阳性率升高,差异均有显著意义(P<0.05)。VIN及鳞癌组织中,组织分级越高,P16蛋白缺失、Cyclin D1过表达越明显。结论:P16蛋白缺失与Cyclin D1过表达在外阴鳞癌发生、发展过程中具有重要作用。
Objective: To investigate the significance of P16 and CyclinD1 expression in squamous cell hyperplasia and squamous cell carcinoma (SCC) of vulva. Methods: The expression of P16 and CyclinD1 was investigated immunohistochemically with SABC method. 32 cases of squamous cell hyperplasia, 32 cases of VIN and 34 cases of SCC of vulva were included. Results:VIN group showed a dramatic reduction in P16 expression and an increase in CyclinD1 expression compared to the normal tissue ( P〈0.01 ) and squamous cell hyperplasia (P〈0.05). In VIN and SCC group, the loss of P16 and overexpression of CyclinD1 occurred mainly in the tissue of higher histological grades. Conclusion: The loss of P16 and overexpression of CyclinD1 may contribute to the happening and developing of SCC of vulva.
出处
《西北国防医学杂志》
CAS
2007年第5期361-363,共3页
Medical Journal of National Defending Forces in Northwest China