帕罗西汀与多虑平治疗急性期脑卒中后抑郁的对照研究

Comparative Study on Paroxetine and Doxepine in Treatment of Post-stroke Depression

目的比较帕罗西汀与多虑平治疗急性期脑卒中后抑郁的疗效及副反应。方法71例急性期脑卒中后抑郁(PSD)病人被随机分为帕罗西汀组(34例)和多虑平组(37例),进行为期6周的治疗研究。以汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)于治疗前及治疗后2周、4周、6周末分别对疗效及副反应进行测评。结果帕罗西汀组总有效率为87.9%优于多虑平组的60.0%(P<0.05);帕罗西汀组副反应的发生率及种类明显低于或少于多虑平组;两组治疗后TESS评分比较均有统计学意义(P<0.05)。结论帕罗西汀与多虑平对急性期脑卒中后抑郁均有一定的疗效。但帕罗西汀与多虑平比较具有药物副反应小、治疗依从性较好等特点。

Objective To study the difference in therapeutic effects and side effects between paroxetine and doxepine in treating post - stroke depression （PSD） in acute stage. Methods Seventy- one patients （pts） with PSD were divided into two groups randomly： Paroxetine group （ n = 34 ） and doxepine group （ n = 37）. The pts were tested with Hamilton rating scale for depression （HMD） and Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the second week, the fourth week, and the sixth week. Results The effective rate of paroxetine was 87.9 %. The effective rate of doxepine was 60.0 % （ P 〈 0.05 ） . The side effects in paroxetine group were lower than that in doxepine group. The TESS in two groups was different significantly pre - treatment and posttreatment （ P 〈 0.05 ）. Conclusion Paroxetine and doxepine were effective for treatment of PSD in acute stage. The side effects were fewer and compliance of paroxetine was better than that in doxepine.