卢戈液染色在早期食管癌诊断中的应用

Clinical use of Lugol's staining in diagnosing early esophageal cancer

目的研究卢戈液染色在早期食管癌诊断中的应用价值,对比染色前后食管癌和异型增生的检出率。方法对306例35～72岁疑似食管病变的患者进行内镜检查,观察并记录食管黏膜颜色、形态和黏膜下血管纹理,卢戈液染色后再观察其颜色变化,并进行组织活检。结果经活检组织学诊断,发现早期食管癌11例,中度和重度异型增生54例。碘染色前后发现食管癌分别为2例和9例,中度和重度异型增生分别为12例和42例,差异均有统计学意义。结论内镜检查中卢戈液染色可显著提高早期食管癌和异型增生的检出率。

[Objective] To evaluate the role of Lugol＇s staining in diagnosing early esophageal cancer. [Methods ] endoscopic exams were performed in 306 people aged 35-72, who were suspected to hawe esophageal pathological changes, Observing and recording the alternation of color and morphology in mucosa and texture of submucosal blood vessels before and after Lugol＇s staining. Biopsy was carried out among all people. [Results] 11 cases of early esophageal cancer, 54 cases of moderate and severe dysplasia were diagnosed through biopsy. The discovery of early esophageal cancer before and after Lugol＇s staining were 2 （0.65%） and 9 （2.9%）; While moderate and severe dysplasia were 12 （3.9%） and 42 （13.7%） respectively with significant statistic difference. [Conclusion] Lugol＂ s staining in endoscopic exam may notablely increase the detecting rate of early esophageal cancer, moderate and severe dysplasia.