肺叶切除时不同方法处理支气管残端的动物实验

Experimental Study on the Closure of Bronchial Stumps Following Pulmonary Resection by Different Techniques

目的:从病理形态学角度,比较肺切除术后不同方法闭合的支气管残端的愈合全过程。方法:对15条犬先后实施三次剖胸多肺叶切陈术(90例);并在离体的犬主、叶支气管上制作残端模型(75个/次);残端分别用开放式sweet's法、器械法及结扎法关闭。动态观察以病理形态学为主的三种残端的愈合过程及相关指标。结果:与缝合者比较,结扎法手术耗时短(P<0.01);结扎者耐压性能好(P<0.01);不加深残端盲袋(P>0.05);形态学表现为愈合早、快、好。结论:结扎后的残端愈合在多方面优于缝合者。

Little is known about the advantages and the disadvantages of different techniques for bronchial stump closure following pulmonary resection in a controlled study. In this experimental study 90 lobectomies were performed on 15 mangrel dogs, weighting 11-20 kg, and 165 bronchial stumps were dealed with three different methods as ligation, stapling and hand interrupted suture. The operated thoracic cavities. the stumps inside and outside, the relationship between [he thoracic cavities and stumps during the operation and the hydrostatic leakage point during different periods after the operation were investigated. In addition.The stumps were histologically examined with H-E staining. The results showed the ligated stumps could resist higher pressure as compared with other techniques, suggesting the ligation was the simplest, quickest and safest method among these three methods.