尿激酶冲击溶栓治疗急性脑梗塞

Impact Thrombolytic Therapy of Acute Cerebral Infarction with Urokinase.

目的研究尿激酶冲击溶栓治疗急性脑梗塞的疗效。方法用尿激酶冲击溶栓治疗３０例急性脑梗塞与常规用维脑路通治疗３２例急性脑梗塞进行比较，两组间年龄、性别及治疗前神经功能缺损程度无明显差异（Ｐ＞０．０５）。结果尿激酶组神经功能恢复明显优于对照组（Ｐ＜０．０１），尿激酶可明显降低血浆纤维蛋白原水平，在治疗过程中无明显不良反应，治疗后总有效率尿激酶组为８６．７％，对照组４６．９％，差异显著（Ｐ＜０．０１）。结论对于发病在１２ｈ内急性脑梗塞应尽快进行溶栓治疗，以期改善脑梗塞的预后。

Objective To study the efficiency of urokinase used in impact thrombolytic therapy of acute cerebral infarction.Method The efficiency of 30 cases on impact thrombolytic therapy with urokinase was compared with that of 32 cases treated with troxeratin.There was no significant difference between the two groups with regard to age,sex and the degree of neurologic deficit before treatment( P > 0.05 ).Results The involved neurologic function of patients in urokinase treated group recovered much better than in control group ( P <0.01).Urokinase significantly lowered the level of plasma fibrinogen and no side reaction was found in the course of treatment.The total effective rate was 86% in urokinase treated group in comparison with 46.9% in control group ( P <0.01).Conclusion A thrombolitic therapy should be given as soon as possible to treat the acute cerebral infarction with an onset within 12 hours,so as to improve the prognosis.