血府逐瘀颗粒对麻醉犬急性心肌缺血的影响

The Effect of Xuefuzhuyu Granule on Acute Myocardial Ischemia in Anesthetized Dogs

目的:观察血府逐瘀颗粒(XFZHYG)对急性心肌缺血犬冠脉循环和血清中乳酸(LA),游离脂肪酸(FFA),过氧化脂质(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性的影响。方法:24只犬随机分为4组,每组6只,分别为模型对照组,阳性对照药血府逐瘀口服液(XFZHYO)5.0 g·kg-1组,XFZHYG 2.5,5.0 g·kg-1组。采用麻醉开胸犬,结扎左冠状动脉前降支(LAD),复制急性心肌缺血模型,测定犬心脏冠脉循环参数;血清中LA、FFA、MDA、SOD、GSH-Px的变化。结果:XFZHYG 2.5,5.0 g·kg-1可降低冠脉阻力(P<0.01,P<0.05),增加冠脉流量(P<0.05),降低血清LA,FFA及MDA含量(P<0.01,P<0.05),提高SOD和GSH-Px活性(P<0.05)。结论:XFZHYG能降低冠脉阻力,增加冠脉流量,对缺血心肌具有保护作用。

Objective： To observe the influence of Xuefuzhuyu Granule （XFZHYG） on coronary circulation and serum enzymes of acute myocardial ischemia in anesthetized dogs. Methods：Twenty-four dogs were devided at random into four groups ： （ 1 ）. model group （2） XFZHYG 5.0 g·kg^-1 group （3） XFZHYG 2.5 g·kg^-1＇ group （4） XFZHYG 5.0 g·kg^-1 group. The parameters of the coronary circulation and the changes of the enzymes in serum were determined by using the acute myocardial ischemia model of left anterior descending branch （LAD） in the anaesthetized dogs. Results： The coronary resistance（ P 〈 0.05） was decreased, the myocardial blood flow was increased （P 〈 0.05 ） in dogs treated with XFZHYG of 2.5,5.0 g·kg^-1 . The activities of serum LA,FFA and MDA were decreased（ P 〈 0.01, P 〈 0.05） ,the SOD and GSH-Px were increased （P 〈 0. 05 ） in acute myocardial ischemia dogs treated with of XFZHYG 2.5,5.0 g·kg^-1. Conclusion：XFZHYG has protective effect on myocardial ischemia through the changes in serum enzymes, decreasing coronary vascular resistance and increasing the myocardial blood flow in dogs.