鼻炎口服液抗过敏作用的实验研究

Experiment Study on Anti-allergic Effects Biyan Oral Liquid

目的:研究鼻炎口服液的抗过敏作用。方法:采用抗血清致大鼠同种被动皮肤过敏、大鼠颅骨骨膜肥大细胞脱颗粒、卵蛋白(OA)引起豚鼠鼻黏膜过敏反应、磷酸组胺致豚鼠过敏反应与2,4-二硝基氯苯(DNCB)诱发的DTH小鼠迟发性超敏反应模型,观察鼻炎口服液的抗过敏作用。结果:与空白对照组比较,鼻炎口服液能显著抑制大鼠同种被动皮肤过敏和豚鼠鼻黏膜过敏反应,阻止大鼠颅骨骨膜肥大细胞脱颗粒、提高豚鼠对磷酸组胺的致敏阈并缩短过敏反应的持续时间,抵制DTH小鼠迟发性超敏反应。结论:鼻炎口服液具有一定的抗过敏作用。

Objective：To study anti-allergic effects of Biyan oral liquid. Methods：The models of rat homologous passive cutaneous anaphylaxis（ PCA）, rat＇s skull periost mast cell（MC） degranulation as well as guinea-pig anaphylaxis of nasal mucosa caused by antiserum, guinea-pig anaphylaxis induced of histamine-phosphate, the delayed-type hypersensitivity（DTH） of mice due to 2,4-dinitrochlorobenzol （DNCB） were employed to study the anti-hypersensitivity effects of Biyan oral liquid. Results： Compared with the control group, Biyan oral liquid could inhibit rat homologous passive skin anaphylaxis and guinea-pig nasal mucosa anaphylaxis, suppress the degranulation of MC in rats, raise allergy threshold induced by histamine-phosphate and curtail continuance of allergic effects. Biyan oral liquid could inhibit delayed-type hypersensitivity of DTH mice. Conclusions ： Biyan oral liquid has the effects of anti-anaphylaxis.