摘要
目的:为围绝经期疾病的动物模型的选择和制备提供参考。方法:查阅近10年来在围绝经期动物模型方面的研究概况,分析比较各主要模型的特点及主要用途。结果:在主要模型中:去卵巢大、小鼠使用较为广泛,而自然衰老大鼠模型更贴近于人类围绝经期变化。针对某一症状的模型中,去卵巢大、小鼠的复合模型运用较多。结论:鼠类围绝经期动物模型已成功应用于围绝经期病症的研究。但模型的内分泌水平等指标确定应更加标准化。
Objective： To offer the references for selecting and preparing animal models of perimenopause. Methods： We summarized the studies on animal models of perimenopause in the last 10 years with analyzing and comparing the characteristics of these models. Results ： In the main animal models, Ovariectomy rats or mice are freguently used. Old rat model is more similar with human being of perimenopause. According to the symptom, the multiplex models of ovariectomy rats or mice are used mostly. Conclusions： Female rat of perimenopause has been used in the study of perimenopause successfully. However, endocrine levels should be standardized for the animal models.
出处
《中国实验方剂学杂志》
CAS
2007年第10期71-72,F0003,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
围绝经期
去卵巢
动物模型
perimenopause
ovariectomy
animal models
