神经生长因子治疗职业性听力损伤的临床研究

Therapeutic effect of nerve growth factor on occupational hearing impairment

目的探索职业性听力损伤（occupational noise-induced heating injury）的有效治疗方法。方法将长期接触噪声、听阚明显下降的132名工人随机设立神经生长因子（nerve growth factor，NGF）组和对照组。NGF组采用基础治疗＋NGF治疗。NGF治疗：冻干粉针NGF2000AU加1ml注射用水稀释，取翳风、完骨二穴，双耳隔日交替注射，28d为一疗程；基础治疗：5％GS＋ATP＋CoA＋VitC，静脉注射，28d为一疗程，1次／d。对照组仅给予基础治疗。结果NGF组与对照组总有效率分别为69．7％、24．2％，NGF组疗效显著优于对照组（P〈0.01）；接触噪声的时间越短疗效越好，其中3年以下、3．8年、8年以上的总有效率分别是100％、67．8％、47．3％，差异均有统计学意义（P〈0.01）；患者年龄越小疗效越好，19．29岁、30—39岁、40岁以上总有效率分别是85．2％、62.5％、53．3％，差异均有统计学意义（P〈0．01）；听力损伤程度越轻，疗效越好，其中高频听损与语频损伤的总有效率分别为81．8％、45．5％，差异均有统计学意义（P〈0.05）。结论NGF治疗职业性听力损伤有较好的疗效。

Objective To explore the therapeutic effect of nerve growth factor （NGF） on occupational noise-induced heating injury, Method One hundred and thirty two workers with occupational noise-induced heating injury were randomly divided into NGF and control groups. The control group only received basic treatment with adenosine triphosphate, coenzyme A, and vitamin C intravenously, in the NGF group NGF 2 000AU was also given by altemately point-injection between right and left ears at Yi-feng and Wan-gu points for 28 days besides the basic treatment. Result It was showed that the general efficiency rate in NGF group was 69.7 %, significantly higher than that of control group （24.2%, P 〈 0.01）. The shorter the exposure to occupational noise, the better the therapeutic efficiency was, the general efficiency rates in the patients with exposed period within 3 years, 3-8 years and more than 8 years were 100%, 67.8% and 47.3% respectively （P 〈 0.01）. And the therapeutic efficiency was better in the people with younger age and milder hearing injury as well, which were 85.2%, 62.5%, 53.3% in the patients with age 19-29 years, 30-39 years and more than 40 years respectively （P 〈 0.01）. And 81.8%, 45.5% in patients only with high-frequency heating injury and those also with low frequency heating injury. Conclusion It is suggested that NGF point-injection has a definite therapeutic effect in occupational noise-induced heating injury.