摘要
研究绞股蓝总皂甙（GPS）对外源性氧自由基所致家兔脑基底动脑损伤的保护作用，外源性氧自由基由电解克氏液产生，电解后，脑基底动脉灌注压及血管壁丙二醛（MDA）含量明显升高，脑基底动脉内皮舒张作用，亚硝酸盐及超氧化物歧化酶（SOD）活性明显降低，GPS25、50、100μg／mL可浓度依赖性地抑制氧自由基诱发脑血管收缩作用，此外GPS100μg／mL还具有明显抑制血管壁MDA生成，保护SOD活性的作用。
Protective effect of gypenoside (GPS)against damges induced by exogenous oxygen free redicals (OFR)on rabbits basilar artery was studied. Exogenous OFR were generated by electrolysis of Krebs solution. The perfusion pressure and malonyldialdehyde (MDA)content in basilar artery were increased, release of Endothelium-derived relaxing factor (EDRF), nitrite content and SOD activity in basilar artery decreased afer OFR damage. GPS 25, 50, 100 μg/mL pretreatment exhibited a concentration dependent decrease in constriction response of basilar artery. Results also showed that GPS 100μg/mL reversed the rise of MDA and the reduction of SOD activity,nitrite and EDRF release.
出处
《中草药》
CAS
CSCD
北大核心
1997年第4期219-221,共3页
Chinese Traditional and Herbal Drugs
基金
湖南省自然科学基金
