青天葵活性部位的体内抗肿瘤作用研究

Study on Anticancer Effect in Vivo of Active Fraction from Nervilia fordii

目的:确定广西特产药材青天葵体内抗肿瘤作用的活性部位。方法:体外初步筛选出的青天葵石油醚和乙酸乙酯活性部位,利用S180和H22小鼠模型进行了体内抗肿瘤试验。结果:青天葵石油醚和乙酸乙酯部位对小鼠移植性肉瘤S180和小鼠肝癌H22均有明显的抑瘤活性,并且对H22荷瘤小鼠可延长其生存期。它们也能改善小鼠的免疫机能。结论:首次确定了青天葵的石油醚和乙酸乙酯部位是体内抗肿瘤作用的有效部位。在此基础上,可以更深入探讨青天葵抗肿瘤作用的有效成分或成分群以及抗肿瘤作用的特点。

Objective：To determine the active fraction with anticancer effect in vivo from Nerviliafordii. Methods：The effective petroleum ether extract and ethyl acetate extract parts preliminary were selected in vitro, then anticancer experiments in vivo were done by S180-mice and H22-mice models. Results：Petroleum ether extract and ethyl acetate extract parts both had obvious anticancer effects to S180-mice and H22-mice,and could prolong H22-mice life. Meanwhile, they could improve the immunoloregulation of mice. Conclusion：It is the first time that the petroleum ether extract and ethyl acetate extract of Nerviliafoadii. are proved to be the effective anticancer fractions in vivo. On this basis, the further studies are needed on active principles or principle group with anticancer effect and the characteristics of this effect in Nerviliafoadii.