代谢综合征不同中医证型中胰岛素抵抗的比较性研究

Research on Correlation Between ISI and Patterns of Metabolic Syndrome in TCM

目的:探讨代谢综合征不同中医证型中胰岛素抵抗的差异性。方法:通过对100例代谢综合症的患者进行中医证型的分类,并观察不同中医证型中胰岛素抵抗(胰岛素敏感指数)的差异性。结果:发现MS各组患者的胰岛素敏感指数(insul in sensitivity index ISI)显著低于正常对照组(P<0.01)。而中医各证型均存在不同程度的胰岛素抵抗水平降低的现象,其值随证型的演变而变化。具体为气阴两虚证<阴虚热盛证<痰瘀互结证<痰浊阻遏(P<0.05)。结论:ISI可反映MS的严重程度,可将ISI作为代谢综合征的中医辨证的客观指标,具有较好的特异性。

Objective： Discussion on correlation between ISI and patterns of metabolic syndrome in TCM. Methods： 100 patients with metabolic syndrome were classified according to patterns of TCM, to observe the correlation between ISI and patterns of metabolic syndrome in TCM. Results： it is found that ISI of patients group is blower to that of control group（ P 〈 0.01 ）. Decrease of hs -CRP varies considerably in group of different patterns , which is shown that： group of hyperactivity in qi and ying syndrome 〈 group of intermingled phlegm and blood stasis syndrome 〈 group of intermingled phlegm and blood stasis syndrome 〈 group of deficiency of retention of phlegm syndrome （ P 〈 0. 05 ）. Conclusion： ISI is an indication of Severity of metabolic syndrome, and can be used as an objective indicator for syndrome differentiation, which has a good specialty.