血液病患者丙型肝炎病毒的感染

Hepatitis C virus infection in patients with haematological disease

为了解血液病患者丙型肝炎病毒 ( HCV)感染率 ,探讨相对危险因素。采用第二代 EL ISA检测抗 - HCV,逆转录巢式双 PCR法检测 HCV RNA。结果发现 :4 5例血液病患者 11例抗 - HCV阳性 ,34例抗 - HCV阴性患者中 ,3例 HCV RNA阳性。综合评价 ,HCV感染率 14/ 4 5( 31.1% )。相关危险因素为反复大量输注未经抗 - HCV筛选的血液及血制品和免疫功能低下。结果表明 :血液病患者 HCV感染率高于普通人群。对献血员进行抗 - HCV筛选后 ,血液病患者 HCV感染率仍较高 。

In order to determine the prevalence and incidence of hepatitis C virus infection in patients with haematological disease and to evaluate their risk factors, anti HCV of the serum were detected by a second generation enzyme liked immunosorbent assay (ELISA) and HCV RNA were tested by nested PCR. Data indicated that 11/45 (24 4%) patients were anti HCV positive and 3 of 34 anti HCV negative cases were found HCV RNA positive. Totally, the HCV infection rate was 31 1% (14/45). The main risk factors for HCV infection are repeated transfusion of unscreened blood and lowered immune function. The incidence of HCV infection in patients with hematological disease is higher than that of general population. Results indicated that the incidence of HCV infection was still high with the detected of anti HCV for screening of blood donors. Conclusively, the assay for screening of blood donors needs to be improved.