骨转移瘤^(89)Sr韧致辐射显像的实验及临床研究

Experimental & clinical study of ^(89)strontium bremsstrahlung imaging in patients with bone metastases

目的:探讨应用韧致辐射原理监测亲骨放射性药物89Sr在人体的分布及其可行性。方法:以2个相同规格、分别装有37MBq的89Sr及99Tcm的玻璃瓶为模型,进行89Sr模型韧致辐射能谱等实验,以确定韧致辐射显像的最佳能量参数。对89Sr治疗后2天～4天的20例患者进行韧致辐射显像,并与99Tcm-MDP骨扫描图比较。结果:89Sr模型与静脉注射89Sr后人体韧致辐射能谱一致,均为多峰连续曲线,其主峰能量约为85KeV。89Sr模型韧致辐射显像的最佳能量、窗宽为85KeV/100%。用实验的能量参数在人体可得到89Sr韧致辐射图像。结论:利用韧致辐射显像能够监测纯β发射体89Sr在体内的分布状况。

To monitor distribution of the bone - seeking radiopharmaceutical ^89Sr in human body by bremsstrahlung phenomenon and evaluate the credibility of the method. Methods： Two similar glass bottles filled with 37MBq of S9Sr and 99Tcm fluid respectively were used as experimental models. S9Sr bremsstrahlung spectrum and energy window was measured and the best energy parameters for bremsstrahlung imaging would be obtained in model experiment. Bremsstrahlung imaging was performed in 20 patients ranging from 2 to 4 days after administering a dose of S9Sr and it was compared with 99Tcm - MDP bone scans. Results： Bremsstrahlung spectrums of SOSr model and human body after injection certain dose of S9Sr were both continual curves with several peaks, whose main energy peaks were both about 85KeV. The optimum energy and energy window of S9Sr imaging in experiment are 85KeV and 100%, respectively. S9Sr imaging of human body would be gotten with above factors. Conclusions： It＇s practicable to monitor distribution of the pure 13 emitter S9Sr in human body utilizing bremsstrahlung method.