B型超声显像仪测量糖尿病和糖耐量减低患者的肾脏体积

Measurement of kidney Volume by B-ultrasound in Patients with Diabetes Mellitus and Impaired Glucose Tolerance

应用B型超声显像仪测定了63例非胰岛素依赖型糖尿病(NIDDM)患者、16例糖耐量减低(IGT)患者和22例正常对照者的肾脏体积。对其中34例NIDDM患者治疗前后进行了比较。结果显示:B型超声可准确测定受试者的肾脏体积。NIDDM患者肾脏体积明显增大(P<0.01);且与糖化血红蛋白(HbA_1c)、餐后2小时血糖(2hBS)明显相关。IGT患者肾脏体积略有增大趋势,但P>0.05。12例代谢改善的NIDDM患者肾脏体积明显缩小(P<0.05);22例代谢未改善者肾脏体积改变不明显。提示代谢控制可改善糖尿病患者早期肾功能改变。

Kidney volumes (KV) were measured by B-ultrasound in 63 non-insulin-dependent diabetes melli-tus (NIDDM) , 16 impared glucose tolerance(IGT) patients and 22 control subjects. It was found that KV could be exactly measured by B ultrasound. The KV in NIDDM patients were significantly larger than those of control and IGT patients (P<0. 01),and the enlargement was significantly correlated with hemoglobin Aic(HbAic)and 2 hour postprandial blood glucose level. The KV in IGT patients were slightly larger than those of controls (P> 0. 05). After 4-month antihyperglycemic treatment in 34 NIDDM patients tit was showed that KV in 12 patients with improved metabolic control were significantly reduced (P<0. 05) , and there were no significant changes of KV in 22 patients with poor metabolic control. This suggested that metabolic control could partially improve early abnormal renal function changes.