血管内皮生长因子在膀胱移行细胞癌中的表达及意义

Expression and Prognostic Significance of Vascular Endothelial Cell Growth Factor(VEGF) in Bladder Transitional Cell Carcinoma

目的:研究血管内皮生长因子(VEGF)在膀胱移行细胞癌中的表达及作用。方法:采用免疫组化S-P法检测45例膀胱移行细胞癌及10例正常膀胱粘膜组织,结合临床和病理资料分析其作用。结果:45例膀胱癌组织中VEGF的阳性表达率为62.22%(28/45),正常膀胱粘膜组织中VEGF均为阴性。在肿瘤中随着病理分级的升高,VEGF表达而增强(Ⅰ级35.2%;Ⅱ级71.43%;Ⅲ级85.71%)。T2~T4期的VEGF表达(79.17%)较Tis^T1期(42.86%)两者间有明显差异(P<0.05)。结论:VEGF蛋白在膀胱癌中的表达与膀胱癌细胞的分化程度有关系,可作为判断膀胱移行细胞癌预后的参考指标。

Objective： To study the expression and prognostic significance of VEGF in bladder transitional cell carcinoma（BTCC）. Methods：Imrnunohistochemistry was used to detect the expression of VEGF in BTCC（n= 45） and normal bladder mucosa（n=10）. Effect was analyzed by both clinical and pathologic data. Results： The positive expression of VEGF in BTCC was 62. 22%（28/45） ,and normal bladder mucosa had no expression. The expression of VEGF was increased with the pathologic grade（grade Ⅰ 35. 2%, grade Ⅱ 71.43 %, grade Ⅲ 85. 71%）. There was signifcante difference in the expression of VEGF between grade T2-T4 （79. 17%） and Tis- T1 （42.86%） （P〈0. 05）. Conclusion.The expression of VEGF in BTCC is related to the cell differentiation, and it can be a marker of determining prognosis of BTCC.