纳洛酮和奥扎格雷钠联合治疗急性脑梗死临床观察

Clinical effect of naloxone with ozagrel sodium on acute cerebral infarction

目的探讨纳洛酮联合奥扎格雷钠治疗急性脑梗死的临床疗效。方法将68例急性脑梗死患者随机分为两组,对照组应用纳洛酮注射液治疗,治疗组联用纳洛酮注射液和奥扎格雷钠注射液。1个疗程后比较两组临床疗效、神经功能缺损评分和血液流变学的变化。结果治疗组总有效率为94.3%,明显优于对照组的70.0%(P<0.05);治疗后治疗组神经功能缺损评分、血液流变学各项指标改善均优于对照组(P<0.05)。结论纳洛酮联合奥扎格雷钠能提高脑梗死患者的临床治疗效果。

[ Objective] To study the effect of naloxone with ozagrel sodium on acute cerebral infarction. [ Methods] 68 patients with acute cerebral infarction were randomly divided into control group and treatment group. The patients in control group were treated with naloxone injection, and patients in treatment group were treated with naloxone injection and ozagrel sodium. After one course of treatment, clinical treatment effect, neurologic impairment score pre- and post-therapy and hemorheological change in two groups were compared. [ Results ] Total effective rates in control group and treatment group were 78.79% and 91.42% , respectively （ P 〈 0.05 ）. Neurologic impairment score pre-therapy was significantly different compared with that post-therapy （ P 〈 0.01 ）. Hemorheology indexes post-therapy were changed significantly （ P 〈 0.05）. [ Conclusion ] Naloxone with ozagrel sodium for acute cerebral infarction can increase clinical therapeutic efficacy.