抗CCP抗体和抗Sa抗体联合检测对老年人RA的临床意义

Significances of anti-cyclic citrullinated peptide antibody and anti-Sa antibody in senile patients with rheumatoid arthritis

目的探讨抗环瓜氨酸肽抗体(抗CCP抗体)和抗Sa抗体联合检测对老年人类风湿关节炎(RA)的临床意义。方法检测85例老年人RA患者的抗CCP抗体和抗Sa抗体,结合临床资料分析。结果抗CCP抗体和抗Sa抗体对RA诊断敏感性分别为77.6%和32.9%,特异性分别为97.4%和95.4%。抗CCP抗体、抗Sa抗体、类风湿因子(RF)均阳性组医生对病情评估、患者对病情评估、Sharp评分、ESR及CRP水平均较阴性组增高。24例RF阴性老年人RA中,抗CCP抗体、抗Sa抗体阳性率分别为50%、41.7%。结论抗CCP抗体和抗Sa抗体联合检测有助于老年人RA的诊断,且二者与患者病情活动性及严重性相关。

[ Objective] To investigate the significance of anti-cyclic citrullinated peptide antibody （anti-CCP antibody） and anti-Sa antibody in senile patients with rheumatoid arthritis （RA）. [ Methods] Anti-CCP antibody was detected by ELISA and anti-Sa antibody was detected by Western blotting in 85 senile patients with B.A. [ Results ] The diagnostic sensitivities of anti - CCP antibody and anti - Sa antibody were 7 7. 6 % and 3 2. 9 % respectively , and specificities were 97.4% and 95.4% respectively. In anti-CCP antibody, anti-Sa antibody and rheumatoid factor （RF） positive patients the scores of physician＇ s global assessment of disease activity, the scores of patients assessment of pain, sharps scores, the levels of ESR and C-reaction protein were higher than those in group all negative. The positive rates of anti-CCP antibody and anti-Sa antibody were 50% and 41.7% respectively in 24 RF negative RA patients. [ Conclusions ] Anti-CCP antibody and anti-Sa antibody are valuable diagnostic parameters for senile patients with RA, which may be related to reactivity and severity of RF.