β-七叶皂苷钠治疗脑转移瘤引起脑水肿的疗效观察

β-aescine Sodium for Brain Edema Caused by Metastatic Brain Tumor: Observation of Curative Efficacy

目的：观察β-七叶皂苷钠治疗脑转移瘤引起脑水肿的疗效。方法：58例经病理学确诊的非颅内肿瘤，经临床表现、头颅CT和／或MRI证实有脑转移后，随机分为甘露醇组（甘露醇1g·kg^-1·d^-1）、β-七叶皂苷钠组（β-七叶皂苷钠20mg·d^-1）和联合治疗组（甘露醇＋β-七叶皂苷钠），各组7d为1个疗程，重者用药7～10d。结果：甘露醇组有效率（80％）与β-七叶皂苷钠组（75％）相似（P〉0．05），均显著低于联合治疗组的91％（P〈0．05）。结论：β-七叶皂苷钠治疗脑转移瘤引起的脑水肿有效，与甘露醇合用疗效更佳。

OBJECTIVE：To observe the efficacy of β- aescine sodium in the treatment of brain edema caused by metastatic brain tumor.METHODS ：A total of 58 patients, who have been diagnosed pathologically as having non- intracranial tumor and verified as having brain metastasis by CT and/or MRI were randomized to mannitol group（at a dose of 1g·kg^-1·d^-1）, β- aescine sodium group（20mg·d^-1）, or combined group（mannitol plus β- aescine sodium group） for 7 days or 7-10d（for the severe cases） .RESULTS： The effective rate in mannitol group（80% ） resembled that in β-aescine sodium group（75% ）, but both were significantly lower than in the combined group（91% ） （ P 〈 0.05）. CONCLUSION ： β- aescine sodium is effective for brain edema induced by metastatic brain tumor,and which had a better efficacy when used concomitantly with mannitol.