STEMI患者中ST段抬高值与hs-CRP相关性研究

The relationship between ST-segment elevation and hs-CRP in patients with ST-segment elevation myocardial infarction

目的研究ST段抬高性心肌梗死(STEMI)患者体表心电图梗死相关导联ST段抬高总和值与血清超敏C反应蛋白(hs-CRP)水平的关系。方法50例STEMI患者发病后送至急诊室即刻及治疗后6h、12h分别行心电图及血清hs-CRP检查,观察治疗前后hs-CRP水平变化,计算梗死相关导联ST段抬高总和值并与hs-CRP水平进行相关性分析。结果患者入院时梗死相关导联ST段抬高总和值(1.41±0.78)mV与血清hs-CRP水平(16.30±22.77)mg/L呈显著正相关(r=0.732,P<0.01);与治疗前(16.30±22.77)mg/L相比,治疗后6h(2.42±3.63)mg/L与治疗后12h(1.58±0.66)mg/L血清hs-CRP水平均明显下降(P<0.01),且二者间的差异具有统计学意义(P<0.05);ST段抬高总和值≥1.5mV的患者中,各种临床事件发生的概率大大增加(P<0.01)。结论STEMI患者心电图ST段抬高总和值与hs-CRP水平呈显著正相关,治疗后hs-CRP水平下降,具有时间依从性。ST段抬高总和值对STEMI患者的预后评估具有指导意义。

Objective To investigate the relationship between the sum of ST-segment elevation on infarct related leads of electrocardiogram （ECG） and the level of serum high sensitive C-reactive protein （hs-CRP） in ST-segment elevation myocardial infarction （STEMI） patients. Methods Total 50 cases with coronary heart diseases were included in the study. ECG examinations were performed in all patients and the serum levels of hs-CRP were detected before and after treatment. Results Before treatment the sum of ST-segment elevation（ 1.41 ± 0.78）mV and the levels of serum hs-CRP（ 16.30± 22.77 ） mg/L Were positively correlated（r = 0.732, P〈0.01 ）. Six and 12 hours after treatment the serum hs-CRP levels decreased to （2.42 ± 3.63 ） mg/L and （1.58 ± 0.66） mg/L, respectively （P〈0.01）. Meanwhile, there were more clinic events in patients with the sum of ST-segment elevation ≥ 1.5mV than in patients with that 〈 1.5mV （P 〈 0.01 ）. Conclusion The sum of ST-segment elevation might be a useful indicator in evaluation the prognosis for STEMI patients.