排铅冲剂驱铅的实验研究

Experiment Study on Lead-removing Effect of Paiqian Granules

目的研究排铅冲剂对染铅小鼠的驱铅作用。方法选用50只18～22g雄性小鼠,随机分为空白对照组、模型对照组和3个实验组。低、中、高剂量组和模型组自由饮用0.1%的三水醋酸铅水溶液;低、中、高剂量组分别灌胃2,4,8g/kgBW剂量的受试药液,模型对照组和空白对照组灌胃去离子水,连续30d。采血,取肝、股骨,用石墨炉原子吸收光谱法测定铅含量。结果3个实验组小鼠肝组织铅含量显著低于模型对照组,但各剂量组小鼠血和骨铅含量无明显影响。结论排铅冲剂有排铅作用。

Objective To study the lead-removing effect of Paiqian Granules in lead-exposed mice. Methods Fifty male mice weighed from 18g to 22g were randomly divided into five groups of blank control, model control and low, middle, high dose groups. In model control and low, middle, high dose groups, the mice freely drank 0.1% lead acetate trihydrate solution. Then, the mice in low, middle, high dose groups were additionally administered with Paiqian Granules by gavage for 30 days at doses of 2, 4, 8g/kg BW, respectively. The mice in blank control and model control groups were given deionized water for 30 days. At the end of the experiment, samples of whole blood, liver and femur were collected for lead detection by GF-AAS. Results Compared with model control group, the lead content in the liver of mice in low, middle, high dose groups significantly decreased. But, there was no significant difference for the lead content in the blood or femur of mice in all groups. Conclusion Paiqian Granules can promote lead excretion in mice.