43例急性白血病的染色体观察

Chromosome analysis in 43 patients with acute leukemia

报告43例初治急性白血病的染色体检查。结果核型异常总检出率为44．2％，急性淋巴细胞白血病（ALL）和急性非淋巴细胞性白血病（ANLL）的核型异常检出率分别为58．3％、38．7％。核型异常表现主要为数目异常，数目异常15例，结构异常3例，结构、数目均异常1例。1例M_2Ph染色体阳性。分析核型与疗效的关系，发现ALL诊断时染色体众数＞50、超二倍体的病人预后并不好。

chromosomes of patients with acute leukemia during first treatment were analysed. The result showed that the positive rate of karyotype abnomalities was 44. 2%. The positive rates of karyotype abnormalities in patients with acute lymphatic leukemia (ALL) and acute nonlymphatic leukemia were 58. 3% and 38. 7% respectively. Karyotype abnormalities consisted of numberical abnomalities (15 cases), structural change (3 cases) and both numberical and structural abnormalities (1 cases).1 patients was found M_2 Ph positives in study of relationship between karyotype and curative treatment. It is observed that patients with ALL whose chromosome mode was greater than 50 and had hyperdiploid had unfavorable prognosis.