降钙素受体基因频率与老年男性骨密度的关系

Studies on the relationship between calcitonin receptor gene frequency and bone mineral density in old aged male

目的探讨老年男性骨密度(BMD)与降钙素受体(CTR)基因频率和基因型频率的关系。方法对深圳地区77例60岁以上男性,用双能X线骨密度仪测定髋部BMD值,分为骨质疏松组和非骨质疏松组,采用聚合酶链反应-限制性长度多态性(PCR-RFLP)技术检测CTR基因型。结果老年男性CTR基因型频率分布依次为CC、CT、TT(分别占0.831、0.169、0),C和T等位基因频率分别为0.916、0.084。不同基因比例:非骨质疏松组以CC型为多,骨质疏松组CT型为多(P<0.01)。结论男性CT基因型者可能为骨质疏松的易患人群。

Objective To investigate the association of calcitonin receptor （CTR） gene frequency and CTR genotypes frequency with bone mineral density （BMD） in aged males. Methods BMDs of the hip of 77 males above 60 years old in Shenzhen region were measured by dual energy X-ray absorptiometry（ DEXA）, afterwards, they were devided into two groups： osteoporosis group and non-osteoporosis group. CTR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results The distribution of CTR genotypes in 77 aged males were CC genotype 0.831, CT genotype 0. 169, TT genotypes 0, and C gene frequency was 0.916 and T gene frequency was 0.084. More CC genotype was found in non-osteoporosis group and more CT genotype in osteoporosis group. Conclusions Males with CT genotype are susceptible to osteoporosis.