可视化方法研究合成硫醚反应动力学

Reaction kinetics of synthesis of thioether by visualization technique

A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidazole),which is an intermediate for lansoprazole.Visualization in sub-microcosmic surroundings was realized to study interfacial phenomenon.The reaction kinetics study by a visualization technique was carried out in a mini-reactor,and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images.Based on the concentration-gray scale standard curves,the reactant concentrations at different times were calculated,and the reaction kinetics curve and reaction rate equation were obtained.Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained.Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.

A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether （ 2-E 3-methyl-4-（ 2,2,2-trifluoro-ethoxy ）-pyridine-2- （methylsulfanyl）-lH-benzoimidazole）, which is an intermediate for lansoprazole. Visualization in submicrocosmic surroundings was realized to study interracial phenomenon. The reaction kinetics study by a visualization technique was carried out in a mini-reactor, and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images. Based on the concentration-gray scale standard curves, the reactant concentrations at different times were calculated, and the reaction kinetics curve and reaction rate equation were obtained. Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained. Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.