强化生活方式干预对2型糖尿病疗效观察

Effectiveness of lifestyle intervention in patients with type 2 diabetes mellitus

目的探讨在药物治疗的基础上强化饮食、运动干预对2型糖尿病患者疗效的影响。方法选择无运动禁忌证的2型糖尿病患者65例,随机分为生活方式干预组(32例)和普通治疗组(33例),检测患者空腹血糖(FPG)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)、高密度脂蛋白胆固醇(HDL-c)、体重指数(BMI)、糖化血红蛋白(HbA1c)及血压等指标,前后自身对照及组间对照评价其治疗效果。结果(1)与单纯药物治疗组比较,生活方式干预组患者的体重、BMI、舒张压、FPG、HbA1c控制明显优于普通治疗组(P<0.05)。(2)经过干预治疗后,2型糖尿病患者的体重、BMI、血压、FPG、HbA1c极显著下降(P<0.01)。结论严格的饮食控制,适量的运动干预能更有效地控制糖尿病患者血糖、HbA1c、血压和体重等危险因素。

Objective To study the short-term impact of lifestyle intervention for type 2 diabetes mellitus. Methods The study group consisted of 65 individuals with type 2 diabetes mellitus randomly assigned to receive intensive lifestyle intervention, or pharmacologic therapy. Assessment of blood pressure, lipids,plasma glucose, body weight and BMI was undertaken. Results （ 1 ） Compared with patients in pharmacologic therapy group, diastolic blood pressure, fasting plasma glucose, body weight and BMI were decreased significantly（ P 〈 0.05 ）. （ 2 ） Blood pressure, plasma glucose, nbA1c, body weight and BMI were decreased in the lifestyle intervention group, with the change being significantly different （ P 〈 0.01 ）. Conclusions Lifestyle intervention improves type 2 diabetes mellitus risk factor status compared with pharmacologic therapy only.