左卡尼汀对30例维持性血透患者生活质量和铁负荷的影响

Effects of L-carnitine on health-related quality of life and iron overload in maintenance hemodialysis patients

目的观察静脉注射左卡尼汀对维持性血液透析(MHD)患者生活质量评分和铁蛋白水平的影响,探讨左卡尼汀对维持性血液透析患者生活质量及铁负荷的影响。方法选择在我院血液透析中心透析龄超过6个月的维持性血液透析患者30例,每次透析结束后,静脉注射左卡尼汀2g,随访3个月,分别在治疗前、治疗3个月末给患者应用SF36系统进行生活质量评分并检测血清铁蛋白浓度。结果治疗3个月后患者的生活质量评分由注射左卡尼汀前的32.90±14.39上升到52.45±12.56;铁蛋白浓度由治疗前的(500±86.07)mg/L下降到(306±78.19)mg/L。结论静脉注射左卡尼汀可明显改善维持性血液透析患者的生活质量,同时铁负荷水平明显下降。

Objective To evaluate the effects of L-carnitine supplementation on life quality （LQ） and iron overload in maintenance hemodialysis （MHD） patients. Methods Thirty MHD patients were recruited,they had undergone hemodialysis for at least six months before the study and were in a stable clinic status without signs of infection or complication. Two gram of L-carnitine was infused to the patients for three months at the end of each dialysis treatment. SF36 （Short Form with 36 questions） score about LQ and the level of serum ferritin（SF） were recorded and analyzed. Results After treatment with L-carnitine for 3 months the score of QL increased from 32.90 ± 14.39 to 52.45 ± 12.56 （ P 〈 0.05 ） ;the SF decreased markedly from 500 ± 86.07ng/ml to 306 ± 78.19ng/ml （ P 〈 0.05 ）. Conclusion Intravenous supplement with L-carnitine in MHD patients appears to be associated with an improvement of health-related quality of life and iron overload status.