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急性有机磷农药中毒患者血清脂蛋白(a)的变化 被引量:2

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摘要 目的探讨急性有机磷农药中毒(AOPP)患者血清脂蛋白(a)[LP(a)]的变化及临床意义。方法用ELISA法检测71例AOPP患者血清LP(a)含量,并与45例对照比较。结果71例AOPP患者血清LP(a)含量在中毒第1、3、5、7天的中位数分别为160、208、310、220 mg/L,中毒第3、5、7天血清12(a)明显高于对照,差异有统计学意义(P<0.01或P<0.05),中毒第3天患者血清LP(a)开始升高,第5天达高峰;中度及重度中毒患者血清LP(a)含量明显高于轻度中毒患者,差异有统计学意义(P<0.05或P<0.01)。结论血清LP(a)可作为AOPP患者组织细胞损伤及炎症的一种标志物。
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2007年第9期567-567,共1页 Chinese Journal of Industrial Hygiene and Occupational Diseases
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  • 1陈灏珠.实用内科学[M]12版.北京:人民卫生出版社,2005.1746-1750.
  • 2张娟文,吕国才,金玉琴,徐根云.急性有机磷中毒患者血清中对氧磷脂酶活力的变化[J].中华劳动卫生职业病杂志,2007,25(10):610-611. 被引量:3
  • 3Chambers JE. PON1 muhitasks to protect health [J]. Proc Natl Acad Sci U S A, 2008, 105(35): 12639-12640.
  • 4Li WF, Furlong CE, Costa LG. Paraoxonase protects against chlorpyrifos toxicity in mice[J]. Toxicol Lett, 1995, 76(3 ): 219-226.
  • 5Li WF, Costa LG, Richter RJ, et al. Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds[J]. Pharmacogenetics, 2000, 10(9 ): 767-779.
  • 6Furlong CE, Cole TB, Jarvik GP, et al. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants[J]. Neurotoxicology, 2005, 26(4 ): 651-659.
  • 7Wang NN, Yuan L, Dai H, et al. Effect of PONI on dichlorvos toxieokinetics[J]. Emerg Med J, 2011, 28(4): 313-315.
  • 8Wang NN, Yuan L, Han ZK, et al. Study of paraoxonase-1 function on tissue damage of dichlorvos[J]. Toxicol Lett, 2010, 196 (2): 125- 132.
  • 9Tsatsakis AM, Aandroutsopoulos VP, Zafiropoulos A, et al. Associations of xenobiotic-metabolizing enzyme genatypes PON1Q192R, PON1L55M and CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece [J]. Xenobiotica, 2011, 41( 10): 914-925.
  • 10Hofmann JN, Keifer MC, Furlong CE, et al. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers[J]. Environ Health Perspect, 2009, 117(9): 1402-1408.

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