摘要
目的研究血清胱抑素C(Cys C)与糖尿病肾病(DN)的关系,探讨其在2型糖尿病(T2DM)早期肾损伤中的价值。方法检测81例T2DM患者的Cys C水平和尿微量白蛋白排泄率(UAER)。结果T2DM患者UAER正常组、微量组及大量组间Cys C水平均有统计学差异(P<0.05,<0.01);随病情加重,Cys C水平升高。T2DM各组Cys C水平与UAER明显相关(P<0.05);Cys C诊断DN的敏感性、特异性为86.5%和93.9%。结论T2DM患者早期肾受损时Cys C已有相应变化,并与DN严重程度相关,有助于DN的早期诊断。
[Objective] To study the relation between serumal cystatin C(Cys C) and diabetic nephropathy(DN),and to explore the value of serum Cys C in diagnosis of early injury of kidney in type 2 diabetic mellitus(T2DM).[Methods] Serum CysC levels of 81 patients with T2DM(including 52 patients complicated DN) were detected by transmitted immunoturbidimetry,urinary microalbumin excretion rate(UAER)was measured.[Results]There was significant difference in Cys C level of T2DM patients with normal UAER,microamount UAER and generous UAER(P〈0.05,〈0.01);The level of Cys C stepped up with pathogenetic condition aggravating.There was a favourable dependability between serumal Cys C level and UAER in different groups of T2DM(r=0.6864,0.7797 and 0.7423,P〈0.05);the diagnostic sensitivity and specificity of serum Cys C for DN were 86.5% and 93.9%.[Conclusion] Serum Cys C changes accordingly when early injury of kidney emerges in patients of T2DM and liscorrelated with severity degree of DN,so it conduces to early diagnosis of DN.
出处
《山东医药》
CAS
北大核心
2007年第28期13-14,共2页
Shandong Medical Journal
基金
温州市科技局立项课题(Y2005A156)
关键词
血清胱抑素C
糖尿病
非胰岛素依赖型
糖尿病肾病
serumal cystatin C
diabetes mellitus,non-insulin-dependent
diabetic nephropathies