血清胱抑素C与2型糖尿病患者尿白蛋白的关系研究

Research on relation between serum cystatin C and urinary albumin in type 2 diabetic

目的研究血清胱抑素C(Cys C)与糖尿病肾病(DN)的关系,探讨其在2型糖尿病(T2DM)早期肾损伤中的价值。方法检测81例T2DM患者的Cys C水平和尿微量白蛋白排泄率(UAER)。结果T2DM患者UAER正常组、微量组及大量组间Cys C水平均有统计学差异(P<0.05,<0.01);随病情加重,Cys C水平升高。T2DM各组Cys C水平与UAER明显相关(P<0.05);Cys C诊断DN的敏感性、特异性为86.5%和93.9%。结论T2DM患者早期肾受损时Cys C已有相应变化,并与DN严重程度相关,有助于DN的早期诊断。

[Objective] To study the relation between serumal cystatin C（Cys C） and diabetic nephropathy（DN）,and to explore the value of serum Cys C in diagnosis of early injury of kidney in type 2 diabetic mellitus（T2DM）.[Methods] Serum CysC levels of 81 patients with T2DM（including 52 patients complicated DN） were detected by transmitted immunoturbidimetry,urinary microalbumin excretion rate（UAER）was measured.[Results]There was significant difference in Cys C level of T2DM patients with normal UAER,microamount UAER and generous UAER（P〈0.05,〈0.01）;The level of Cys C stepped up with pathogenetic condition aggravating.There was a favourable dependability between serumal Cys C level and UAER in different groups of T2DM（r=0.6864,0.7797 and 0.7423,P〈0.05）;the diagnostic sensitivity and specificity of serum Cys C for DN were 86.5% and 93.9%.[Conclusion] Serum Cys C changes accordingly when early injury of kidney emerges in patients of T2DM and liscorrelated with severity degree of DN,so it conduces to early diagnosis of DN.