氨甲喋呤治疗异位妊娠两种肌肉注射方案的临床比较

Comparison of different intramusculary protocol in the treatment of ectopic pregnancy with methotrexate

目的:比较异位妊娠患者使用氨甲喋呤(MTX)单次肌肉注射和分次肌肉注射方案的治疗效果。方法:对两组异位妊娠患者的年龄、血β-HCG、异位妊娠包块大小、住院天数、治疗结果等进行比较。结果:单次肌肉注射和分次肌肉注射治疗方案的成功率分别是86.11%和87.50%,两者比较无显著性差异。结论:氨甲喋呤单次肌肉注射方案和分次肌肉注射方案疗效相当,但单次肌肉注射方案给药方便,更易为患者接受。

Objective： To compare efficacy of ectopic pregnancy patients treated with single - dose or muhidose methotrexate （MTX） protocols. Methods： The age of patient, gestational age, serum human chorionic gonadotropin, overall ectopic mass size, history of ectopic pregnancy, number of treatment days in hospital, and outcome in consecutive patients with ectopic pregnancy treated with methotrexate were compared. Results： Successful rates were 86. 11% and 87. 5% respectively, there were no significantly differences. Conclusion： Single - dose methotrexate protocols is as effective as multidose methotrexate protocols, but the former is more convenient than the latter.