生殖道病原体感染与不孕症的关系

Relationship between for genital pathogens infection and infertile women and men

目的:探讨淋球菌(NG)、沙眼衣原体(CT)、溶脲脲原体(UU)、单纯疱疹病毒2型(HSV-2)和弓形体(Tox)感染与不孕症之间的关系。方法:采用聚合酶链反应(PCR)检测157例不孕症患者,同时采用单对引物PCR和复合PCR对照NG、CT和UU的检测结果,选择有孕育史的77例健康个体作为对照。结果:NG、CT、UU、HSV-2和Tox检出率分别是9.58%、22.08%、33.75%、5.42%和3.75%,NG、CT和UU检出率均高于对照组,差异具有统计学意义(P<0.01),重叠感染率为22.29%(35/157)。单对引物PCR和复合PCR检出符合率分别是NG100%、CT91.18%和UU81.13%。结论:NG、CT和UU感染与不孕不育症密切相关,并且不孕症患者可出现多种病原体的重叠感染。

Objective： To elucidate the association of N. gonorrhoeae （NG）, chlamydia trachomatis （CT）, ureaplasma urealyticum （UU） , herpes simplex virus （HSV）, and toxoplasma （Tox） infection and infertile disease in women and men and to set up the simple method in detecting co -infection. Methods： Five pathogens were examined respectively by PCR technique in 157 infertile patients assigned as monitored groups, 77 normal procreation assigned as control groups. Clinical specimens were also examined by multi - PCR. The positive rates were then compared between monitored groups and control groups. Results： There were significant differences in the positive rate of NG, CT and UU between monitored groups and control groups. The co - infection rate was 22.29% （35/157） . There were the accord rate of NG 100%, CT 91.18% and UU 81.13% between single - PCR and multi -PCR. Conclusion： The infertility in women and men is closely correlated with NG, CT, and UU infection. The rate of virus co - infection in infertile patients is higher.