妊娠期肝内胆汁瘀积症胎盘生长因子的表达与围生儿缺氧的关系

The relationship between the perinatal hypoxia and expression of placenta growth factor in patients with intrahepatic cholestasis of pregnancy

目的:探讨妊娠期肝内胆汁瘀积症(ICP)患者胎盘中胎盘生长因子(PLGF)的表达水平与围生儿缺氧的关系。方法:以40例ICP患者(ICP组)和40例正常晚期妊娠妇女(对照组)为研究对象,观察两组患者围生儿缺氧情况;采用免疫组织化学方法测定两组胎盘中胎盘生长因子的表达水平。结果:ICP组围生儿缺氧的发生率显著高于对照组(32.5%vs7.5%,P<0.025);ICP组胎盘中PLGF表达水平明显低于对照组(P<0.01);围生儿缺氧风险有随着PLGF表达水平降低而增加的趋势(P<0.05)。结论:妊娠期肝内胆汁瘀积症患者胎盘PLGF表达下降,影响胎盘功能,可能是ICP并发围生儿缺氧的原因之一。

Objective： To explore the relationship between the expression level of placenta growth factor （PLGF） in placentas and perinatal hypoxia of patients with intrahepatic cholestasis of pregnancy （ICP） . Methods： Samples were obtained from 40 cases with ICP and 40 normal third trimester pregnant women （ control group） to observe the perinatal hypoxia of the two groups. Placenta growth factor level in placentas of the two groups was detected by immunohistochemistry method. Results： Perinatal hypoxia rate of ICP group was significantly higher than that of the control group （32.5% vs 7. 5% , P 〈0. 025） ; Placenta growth factor expression level in placentas of ICP group was lower than that of the control group significantly （P 〈 0. 01 ） ; An increasing trend of perinatal hypoxia rate following the decrease of placenta growth factor expression level was found （P 〈 0.05） . Conclusion： The lower expression of PLGF in placentas from ICP patients affects placenta function, which may be one of the reasons leading to perinatal hypoxia.