不同类型高脂血症患者脂蛋白残粒胆固醇水平的检测及意义

The significance of plasma remnant lipoprotein cholesterol determination in different type of hyperlipidemia

目的检测不同类型高脂血症患者脂蛋白残粒胆固醇(RLP-C)水平并探讨其临床意义。方法采用免疫分离法分别测定62例高胆固醇(HTC)血症患者、91例高三酰甘油(HTG)血症患者、59例混合型高脂血症(MHL)患者和61名血脂正常的健康对照组血浆RLP-C的水平,并比较RLP-C与其他血脂指标的相关性。结果HTG血症和MHL患者血浆RLP-C浓度分别为(0.43±0.29)mmol/L和(0.30±0.21)mmol/L,明显高于对照组[(0.19±0.12)mmol/L,P<0.01、P<0.05],而HTC血症患者血浆RLP-C浓度[(0.21±0.13)mmol/L]与对照组比较差异无统计学意义(P>0.05)。RLP-C与TG和极低密度脂蛋白胆固醇(VLDL-C)呈正相关(r=0.78、0.68,P均<0.01)。结论HTG和MHL患者血浆RLP-C水平显著升高。

Objective To determine the level of plasma remnant lipoprotein cholesterol（RLP-C） in different type of hyperlipidemia and evaluate its clinical significance. Methods The plasma RLP-C levels in 62 hypercholesterolemic（HTC）,91 hypertriglyceridemic（HTG）,59 mixed hyperlipidemic（MHL） patients and 61 controls with normal serum lipid level were assayed by immunoseparation method.The correlation between RLP-C and other lipid parameters was also analyzed. Results The plasma RLP-C concentration in patients with HTG and MHL（[0.43±0.29]mmol/L and（[0.30）±0.21]mmol/L） was significantly higher than that in the controls（[0.19±0.12]mmol/L,P〈0.01,P〈（0.05）.） The plasma RLP-C concentration in HTC patients（[0.21±0.13]mmol/L） was not significantly different than that in the controls（[0.19±0.12]mmol/L,P〉（0.05）.） The plasma RLP-C concentration was significantly correlated with triglyceride（TG） and very low density lipoprotein cholesterol（VLDL-C）（r=0.78,0.68,P〈0.01）. Conclusions The plasma RLP-C level increases significantly in HTG and MHL patients. Remnant lipoprotein