孕妇血清羊水和新生儿脐血胃泌素的测定

Assay of gastrin in pregnant women's serum and amniotic fluid and in neonatal umbilical cord blood.

用放射免疫法测定７５例孕１２～４２周健康孕妇的血清、羊水和２６例新生儿脐血胃泌素的浓度。结果：随孕周的增加羊水和血清胃泌素的浓度不断降低，足月后又明显升高，母血清胃泌素浓度高于羊水，以中期妊娠为明显（Ｐ＜０．０５），脐血胃泌素浓度在晚期妊娠时较低，足月后升高接近母血清和羊水水平。提示：胃泌素浓度的变化是机体在妊娠期的一种生理性代偿作用，并可能与胎儿消化器官发育成熟和功能完善有关。

Objective:To study the relationship between the serum gastrin and the growth and maturity of fetal digestive organs.Design:The concentrations of gastrin in maternal serum and amniotic fluid were measured in 75 normal pregnant women and in 26 cases of neonatal cord blood,using the method of radioimmunoassay.Results:The gastrin concentrations of amniotic fluid and serum decreased significantly with the advancing of pregnancy,while it increased obviously at term.The gastrin level in maternal serum was higher than that in amniotic fluid (P<0.05).The gastrin level in neonatal cord blood was low in the third trimester of pregnancy,but also increased at term. Conclusion:The changes of gastrin level may be related to the growth and maturity of fetal digestive organs and their functions. \ \