多发性Kimura病1例报道及文献复习

Multiple kimura’s disease:report of one case and review of the literature

报道1例12岁男性多发性Kimura病病例,并复习Kimura病的国内外相关文献。Kimura病的发病率低,病因未明,以中青年男性多见,临床上常表现为长期存在并易于反复的头颈部淋巴结肿大或软组织肿块、嗜酸性粒细胞及IgE升高。病理学检查可见炎性细胞增生、浸润,淋巴滤泡形成,不同程度的纤维化、血管增生反应,无特异性的免疫组化标记。手术、放射治疗及皮质激素治疗可取得良好疗效。预后视有无脏器受累而有所不同,复发率较高。

A case of multiple kimura＇ disease（KD） in a 12-year-old boy was reported and the literatures regarding to KD were reviewed.KD is rare in clinic,unclear in etiopathogenesis ,predominant in young and middle aged male. The clinical features included enlarged lymph nodes and mass in soft tissue which were always predilected for the head and neck region,eosinophilia and serum IgE rising almost in all patients. The pathological characteristics of KD for diagnosis was the marked infiltration of eosinophilis, variable degrees of fibrosis and proliferation of thin walled capillary venules. There was no characteristic marker of immunohistochemistry in the diagnosis of KD. Surgical excision, radiotherapy and steroid therapy could take good effects.The outcome of KD was depended on involvement of organs and recurrence often occurred.