小儿支气管肺炎血清次黄嘌呤水平变化及其临床意义

SERO-HYPOXANTHINE CHANGES IN CHILDREN WITH BRONCHOPNEUMONIA AND THEIR CLINICAL SIGNIFICANCE

观察了55例12月～5岁不同病期支气管肺炎患儿血清次黄嘌呤（Hx）、血乳酸盐（UA）、脂质过氧化物（LPO）的变化及其与血气分析和临床之间的关系，并与正常同龄儿比较。肺炎急性期血清HX、UA及LPO均高于恢复期和对照组（P＜0．001），恢复期Hx有所下降，但仍高于对照组，重症肺炎上述三个指标均高于普通型肺炎，且Hx与UA和LPO呈显著正相关。提示Hx是一个敏感的缺氧指标，较UA更好地反映组织细胞的缺氧和能量代谢状态。

The authors observed the changes ofsero-hypoxanthine (Hx), uric acid (UA), and lipidperoxide (LPO) and analyzed their correlations withblood gas analysis and clinical manifestation in children with bronchopneumonia. The subjects consisted of 55 bronchopneumonia patients and 22 normalchildren, aged from 2 months to 5 years old. Theresults showed that the level of sero-Hx, UA andLPO was much higher in the acute stage of pneumonia than in the recovery stage and in the controlgroup (P <0.001 ). Hx was declined in the recoverystage, but still remained in higher level than that ofcontrol group. Moreover, Hx, UA and LPO weresignificantly higher in severe pneumonia than thosein common one (P <0.001 P <0.01). There wasstronger positive correlation to be found among Hx,UA and LPO. We conclude that Hx is a sensitive indicator for hypoxemia in children with bronchopneumonia.