糖尿病对肝硬化患者并发自发性细菌性腹膜炎的影响

The influence of diabetes mellitus on cirrhosis with spontaneous bacterial peritonitis

目的探讨合并糖尿病对肝硬化患者并发自发性细菌性腹膜炎（SBP）的影响。方法选择2000年1月-2004年12月收治的肝硬化合并腹水患者3079例，在腹水细菌培养阳性的148例患者中，合并糖尿病患者49例（合并糖尿病组），未合并糖尿病患者99例（非合并糖尿病组）；肝硬化合并糖尿病的405例患者中；根据有无SBP又分为SBP组（246例）和无SBP组（159例）。记录相关情况并进行分析。结果在腹水细菌培养阳性的患者中，合并糖尿病组患者转归差，且真菌感染和混合感染发生率高。在肝硬化合并糖尿病的患者中，SBP组转归差。结论肝硬化患者合并糖尿病时更易并发SBP，且抗感染疗效及预后差，更易发生真菌及混合感染；糖尿病与感染间存在相互作用。

Objective To investigate the influence of diabetes meUitus on cirrhosis with spontaneous bacterial peritonitis （SBP）. Methods The total of 3079 cirrhosis patients with ascites between January 2000 and December 2004 were included. In 148 patients with positive SBP,49 eases had diabetes mellitus and the other 99 cases had not. Four hundred and five patients with diabetes mellitus were divided into two groups：none SBP group and SBP group. The data were recorded and analyzed. Results In 148 patients whose ascites were positive, the therapeutic efficacy of patients with diabetes mellitus was worse and could be infected easily. In 405 patients with diabetes mellitus, the therapeutic efficacy of patients with SBP was worse. Conclusions If the patients of cirrhosis had diabetes meUitus,they may be easy to complicate with SBP, and the curative effect of treatment by antibiotic is worse. Mixed infection and infection of fimgi often occur. Diabetes meUitus and infection is interactional.