慢性心力衰竭患者血清IL-1β、TNF-α、血浆AngⅡ含量及临床意义

Concentrations of serum TNF-α,IL-1β,plasma Ang Ⅱ and its clinical significance in the patients with chronic heart failure

目的探讨慢性心力衰竭患者血清肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β、血浆血管紧张素Ⅱ（AngⅡ）含量及其临床意义。方法62例慢性心力衰竭患者（慢性心力衰竭组），按NYHA分级又分为3组：NYHA分级Ⅱ级组20例，NYHA分级Ⅲ级组20例，NYHA分级Ⅳ级组22例；另选择15例健康人作为对照组。测定血清TNF-α、IL-1β及血浆AngⅡ含量。结果慢性心力衰竭组血清TNF-α、IL-1β及血浆AngⅡ含量显著高于对照组。慢性心力衰竭患者NYHA分级各组间血浆AngⅡ含量比较，差异也有统计学意义。相关分析显示血浆AngⅡ含量与血清TNF-α、IL-1β含量呈显著正相关。结论慢性心力衰竭患者血清TNF-α、IL-1β及血浆AngⅡ共同参与慢性心力衰竭的发病机制，它们之间可能还有相互作用。

Objective To investigate the concentrations of serum TNF- α, IL-1β , plasma Ang Ⅱ and its clinical significance in the patients with chronic heart failure（CHF）. Methods CHF group included 62 patients. They were divided into three groups according to cardiac fimction （NYHA classification）, NYHA Ⅱ group（20 patients）, NYHA In group（20 patients）, NYHA Ⅳ group（ 22 patients）. Control group included 15 healthy volunteers. Serum concentrations of TNF-α,IL-1 β and plasma Ang Ⅱ were measured. Results The results showed that concentrations of TNF-α , IL- 1β , plasma Ang Ⅱ in CHF group were significantly higher than those in control group. Concentration of Ang Ⅱ showed significant difference among NYHA Ⅱ group,NYHA In group and NYHAⅣ group. Serum concentrations of TNF-α and IL-1β were positively correlated with plasma concentration of Ang Ⅱ . Conclusions Changes of concentrations of TNF-α ,IL-1β and Ang Ⅱ in the patients with CHF play roles in the pathogenic mechanism of CHF. They may interact and influence each other in the pathogenic mechanism of CHF.