膀胱移行细胞癌EGF、EGFr含量的测定及意义

Expression of Epidermal Growth Factor and Its Receptor in Transitional Cell Carcinoma of Human Urinary Bladder

用125I标记分析法对25例膀胱移行细胞癌组织和14例正常膀胱组织进行了EGF、EGFr含量测定。表明EGF、EGFr在肿瘤组织中的含量明显高于癌旁正常对照组织（P＜0.05）。肿瘤组织各病理分级组之间EGF、EGFr含量随病理分级增高，有明显增高趋势，但经统计学处理，尚未观察到有显著性差异（P＞0．05）。25例病人术后随访，1年内肿瘤复发的5例患者中，4例肿瘤组织中有EGFr较高水平的表达。

The expression of epidermal growth factor (EGF) and EGF receptor (EGFr)is at high level insome human tumor tissues. The content of EGF and EGFr were examined by l25I-labeled-EGF binding analysis in25 cases of bladder transitional cell carcinoma and 14 cases of normal bladder mucosa. The relationship betweenthe value of content and prediction of prognosis and relapse of bladder tumor was discussed.