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癫痫苔藓纤维出芽的研究进展

Research advances of mossy fiber sprouting in epilepsy
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摘要 癫痫的发病机制非常复杂．迄今尚未完全阐明。苔藓纤维出芽（mossy fiber sprouting，MFS）作为癫痫发作后最常见的病理改变之一，与癫痫的反复自发性发作密切相关。近年来，已有不少的研究从苔藓纤维出芽的角度探讨癫痫的发生、发展．并为癫痫的治疗提出新的观点。现就癫痫苔藓纤维出芽的研究进展做一综述。
作者 徐祖才 陈阳美
机构地区 重庆医科大学附属第二医院神经内科
出处 《中华神经医学杂志》 CAS CSCD 2007年第10期1073-1075,共3页 Chinese Journal of Neuromedicine
关键词 苔藓纤维出芽 癫痫模型 神经递质 神经营养因子 Mossy fiber sprouting Epilepsy model Neurotransmitter Neurotrophic factor
分类号 R742.1 [医药卫生—神经病学与精神病学]
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  • 2Shibley H, Smith BN. Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice[J]. Epilepsy Res, 2002, 49(2): 109-120.
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  • 6Bausch SB, McNamara JO. Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures[J]. J Neurophysiol, 2004, 92(6): 3582-3595.
  • 7Sloviter RS, Zappone CA, Harvey BD, et al. Kainic acid-induced recurrent mossy fiber innervation of dentate gyrus inhibitory interneurons: possible anatomical substrate of granule cell hyper-inhibition in chronically epileptic rats [J]. J Comp Neurol, 2006, 494(6): 944-960.
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中华神经医学杂志
2007年 第10期

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