Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways

造血的干细胞(HSC ) 是为所有系的血细胞的终生的产生负责的房间的一张稀罕人口。以便维持他们的数字， HSC 必须建立在自强的反对房间命运之间的平衡(在哪个作为 HSC 工作的能力被保留) 并且造血的区别的开始。Multiplesignaling 小径在 HSC 房间命运的规定被含有。小径的一个如此的集合是 ligands 的 Wnt 家庭激活的那些。Wnt 发信号小径玩关键角色 duringembryogenesis，这些小径的解除管制在稳固的肿瘤的形成被含有。发信号的 Wnt 也从多重纸巾在干细胞的规定起一个作用，例如胚胎、表皮、肠的干细胞。然而，在 HSCbiology 发信号的 Wnt 的功能仍然是争论的。在这评论，我们将讨论成年 HSC 的基本特征，集中于 HSCand 的规定并且它的规章的微型环境，“壁龛”它由表明小径的 Wnt 的壁龛。

Hematopoietic stem cells （HSCs） are a rare population of cells that are responsible for life-long generation of blood cells of all lineages. In order to maintain their numbers, HSCs must establish a balance between the opposing cell fates of self-renewal （in which the ability to function as HSCs is retained） and initiation of hematopoietic differentiation. Multiple signaling pathways have been implicated in the regulation of HSC cell fate. One such set of pathways are those activated by the Wnt family of ligands. Wnt signaling pathways play a crucial role during embryogenesis and deregulation of these pathways has been implicated in the formation of solid tumors. Wnt signaling also plays a role in the regulation of stem cells from multiple tissues, such as embryonic, epidermal, and intestinal stem cells. However, the function of Wnt signaling in HSC biology is still controversial. In this review, we will discuss the basic characteristics of the adult HSC and its regulatory microenvironment, the ＂niche＂, focusing on the regulation of the HSC and its niche by the Wnt signaling pathways.