血管生成在子宫内膜癌中的临床研究

Clinical Research of Angiogenesis in Tumorigenesis and Development of Endometrial Carcinoma

目的研究血管生成在子宫内膜癌发生发展中的作用。方法采用免疫组织化学SP的方法,研究50例子宫内膜癌组织及20例正常子宫内膜组织中微血管密度(MVD)。结果子宫内膜癌中MVD(19.21±8.15)显著高于正常子宫内膜(8.12±2.93),P<0.05,且与临床分期、组织分化程度和肌层侵润深度显著相关(P<0.05)。结论子宫内膜癌的发生发展中,血管生成起到非常重要的作用,MVD对子宫内膜癌的预后判断有重要价值。

Objective To investigate the role of angiogenesis in the tumorigenesis and devel- opment of endometrial carcinoma（EC）. Methods All 50 endometrial carcinoma and 20 control were in- vestigated for microvessel density by immunohistochemically. Results MVD was significantly higher in EC than that in normal endometrium. （ 19. 21 ± 8. 15 vs 8. 12 ± 2. 93, P 〈 0. 05） and was significantly correlated with clinical stage, histological grade and myometrial invasion （P 〈 0. 05） . Conclusion Angiogensis play an important role in tumorigenesis and development of endometrial carcinoma. MVD may be an valuable indicator in prognosis judgement in patients with endometrial carcinoma.