期刊文献+

大肠癌中微卫星位点不稳定性检测的研究 被引量:3

下载PDF
导出
摘要 微卫星不稳定性(MIN)是错配修复基因突变的表型标记,是结直肠癌(CRC)发生的一个新机理。目前,大部分文献报道认为,MIN为HNPCC和其他HNPCC相关癌易患者提供新的筛选方法。在CRC中检测有关微卫星位点的不稳定性,将有助于进一步阐明CRC的发生机制,明确有关基因的作用,选择合适的MIN位点还为CRC的诊断、鉴别诊断和估计预后提供帮助。
作者 张宇伟
出处 《国外医学(遗传学分册)》 1997年第3期128-131,共4页 Foreign Medical Sciences(Section of Genetics )
  • 相关文献

同被引文献14

  • 1邱红明.遗传性非息肉病性大肠癌分子病理学研究进展[J].国外医学(遗传学分册),1995,18(4):176-179. 被引量:2
  • 2卢小梅,陈书媛,黄受方,张长淮.乳腺癌石蜡切片中显示雌、孕激素受体方法和阳性结果判断标准的探讨[J].中华病理学杂志,1996,25(6):329-331. 被引量:28
  • 3Miesfeld R,Krystal M,Arnheim N,et al A member for a new reperted sequence family which is conserved throughout encatyotic evolution is found between the humanδandβglobin genes[J].Neudeic Acid Res,1981,9(22):5931-5947.
  • 4Sirchia S M,Pariani S,Rossella F,et al.Cytogenetic abnormalities and microsatellite instability in endometrial adenocarcinoma[J].Caner Genet Cytogenet,1997,94(2):113-119.
  • 5Thibodeau S N,French A J,Roche P C,et al.Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes[J].Cancer Res,1996,56(23):4836-4840.
  • 6Peiro G,Diebold J,Lohse P,et al.Microsatellite instability,loss of heterozygosity,and loss of hMLH1 and hMSH2 protein expression in endometrial carcinoma[J].Hum Path,2002,33(3):347-354.
  • 7Tomita S,Miyazato H,Tamai O,et al.Analyses of microsatellite instability and the transforming growth factor-βreceptor type Ⅱgene mutation in sporadic human gastrointestinal cancer[J].Cancer Genet Cytogenet,1999,115(6):23-27.
  • 8Tomita S,Deguchi S,Miyaguni T,et al.Analysis of microsatellite instability and the transforming growth factor-βreceptor type Ⅱgene,mutation in sporadic breast cancer and their correlation with clinicopathological features[J].Breast Cancer Res Treat,1999,53(3):33-39.
  • 9Burks R T,Kessis T D,Cho K R,et al.Microsatellite instability in endometrial carcinoma[J].Oncogene,1994,9(12):1163-1166.
  • 10Simpkins S B,Bocher T,Swisher E M,et al.MLH1 promoter methylation and gene silence is the primary cause of microsatellite instability in sporadic endometrial cancers[J].Human Molecular Genetics,1999,18(4):661-666.

引证文献3

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部