1Wang J, Kim S, Kovacs F, et al. Structure of the transmemb-rane region of the M2 protein H(+) channel. Protein Sci[J]. 2001,10(11): 2241-2250.
2Okada A, Miura T, Takeuchi H. Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza a virus[J]. Biochemistry, 2001, 40(20): 6053-6060.
4Kendal A P, Klenk H D. Amantadine inhibits an early, M2 p-rotein-dependent event in the replication cycle of avian influenza (H7) viruses[J]. Arch Virol, 1991, 119(3-4): 265-273.
5Bron R, Kendal A P, Klenk H D, et al. Role of the M2 pro-tein in influenza virus membrane fusion: effects of amantadine and monensin on fusion kinetics. Virology, 1993, 195(2): 808-811.
6Black R A, Rota P A. Gorodkova N, Cramer A, et al. Prod-uction of the M2 protein of influenza A virus insect cells is enhanced in the presence of amantadine[J]. J Gen Virol, 1993, 75: 1673-1677.
7Frace A. M, Klimov A. I, Rowe T, et al. Modified M2 pro-teins produce heterotypic immunity against influenza A virus[J]. Vaccine, 1999, 17: 2237-2244.
8Sansom M S, Kerr I D, Smith G R, et al. The influenza A virus M2 channel: a molecular modeling and simulation study[J]. Virology, 1997, 233(1): 163-173.
9Watanabe T, Watanabe S, Ito H, et al. Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity[J]. J Virol, 2001, 75(12): 5656-5662.
10Hay A J, Wolstenholme A J, Skehel J J, et al. The molecular basis of the specific anti-influenza action of amantadine[J]. EMBO J, 1985, 4(11):3021-3024.
