静脉输注丙种球蛋白治疗特发性血小板减少性紫癜

Curative effect of intravenous injection gamma globulin threapy on idiopathic thrombocytopenic purpura

目的:分析静脉输注丙种球蛋白治疗特发性血小板减少性紫癜(ITP)的疗效。方法:静脉输注丙种球蛋白(IVIG)0.4g·kg-1·d-1,连用5d。结果:25例患者经治疗后,显效11例(44%),其中基本治愈5例(20%);良好效果6例(24%);进步4例(16%);无效4例(16%),总有效率为84%。结论:治疗重症、难治性ITP患者,IVIG是一种安全、有效、无不良反应的治疗方法。特别对≤14岁的患儿和初治病例疗效更佳。并可反复使用,复发患者用糖皮质激素治疗仍有效。

Objective：To investigate the curative effect of intravenous injection gamma globulin（IVlG） threapy on idiopathic thrombocytopenic purpura （ITP）. Method..Dosage of IVIG was 0.4 g·kg^-1·d^-1 on d1-5. Result：Among 25 patients, 11 patients （44%） with ITP achieved remarkably excellent effects, 5 patients （20%） arrived at elementary curement, 6 patients （24%） acquired good effects, 4 patients （16%） imporved and 4 patients （16%） were without response. Total effective rate was 84%. Conclusion： To severe or refractory ITP, IVIG was a safe, effective treatment without obvius side effect. Currative effect was much better in initial patients or those younger that 14 years old. IVIG could be used repeatedly. Glucocorticoid could be effective in those relapsing patients.