不同药液组合雾化吸入预防开颅术后肺部并发症150例效果观察

Observation on the effect of atomizing inhalation of combined drug solution on prevention of complication in the lung of patients with craniotomy in 150 cases

目的：探讨不同药液组合雾化吸入对预防开颅术后患者肺部并发症的效果。方法：将150例脑肿瘤术后患者分为3组：A组用生理盐水加α-糜蛋白酶、地塞米松雾化吸入;B组用生理盐水加痰易净（N-乙酰半胱氨酸）、地塞米松雾化吸入;C组用注射用水加痰易净、地塞米松雾化吸入。观察3组患者术后1-5 d的痰量及痰液粘稠度变化。结果：C组术后各时段痰液粘稠度、排痰量与A、B组比较均有显著性差异（P〈0.05）;C组术后1-5d痰液粘稠度显著降低,痰量显著减少。结论：开颅术后患者采用注射用水加痰易净、地塞米松雾化吸入,可有效促进患者术后排痰,预防肺部感染等并发症。

Objeetive： To explore the effect of atomizing inhalation of combined drug solution on prevention of complication in the lung of patients with craniotomy. Methods： One hundred and fifty patients with brain tumor resection were divided into 3 groups. Atomizing inhalation of normal saline combined with α - chymotrypsin and DEX was used in group A ; The patients in group B were given normal saline combined with mucofilin and DEX by atomizing inhalation; in group C, atomizing inhalation of injection water combined with mucofilin and DEX was applied. Observation was made on amount and viscosity of phlegm of patients of the three groups in the duration of one to five days after operation. Results ： Comparing with group A and B, the amount and viscosity of phlegm of patients in group C have significant difference （ P 〈 0. 05 ） ; the amount and viscosity of phlegm of patients in group C reduced and lowered obviously. Conclusion： Atomizing inhalation of injection water combined with mucofilin and DEX can effectively accelerate ejecting phlegm after operation so as to prevent from lung infection.