谷胱苷肽S转移酶在涎腺肿瘤中的表达

Expression of Glutathione S-transferase Pi in Salivary Gland Tnumors

用免疫组织化学方法对106例涎腺肿瘤中谷胱苷肽S转移酶π(GST-π)的表达进行了研究.GST-π主要表达在高分化粘液表皮样癌中的表皮样细胞,在其它涎腺肿瘤中表达较弱.该结果提示:GST-π可作为高分化粘液表皮样癌的标志,有助于肿瘤分级.本文还对涎腺肿瘤 GST-π表达情况与肿瘤的抗化疗作用的关系进行了讨论.

The aim of this study was to investigate the expression of gultathione S-tranferase Pi (GST-π) in salivary gland tumors (106 cases), using immunohistochemical method. The results showed that GST-π was mainly demonstrated in epidermoid cells of high differentiated mucoepidermoid carcinoma, whereas most of other types of salivary gland tumor was GST-π negative. In the occasionally GST-positive cases such as in pleomorphic adenoma, only a few positive cells were noted. The results suggest that GST-π may be a marker for mucoepidermoid carcinoma and useful in identifying the malignant grade of this tumor. The possible role of GST-playing in antichemotherapy of salivary gland tumor was also discussed.