双时相^(18)F-FDG PET显像用于肿瘤良恶性鉴别诊断

Dual phase ^(18)F-FDG PET imaging in the differential diagnosis of malignant and benign lesions

目的探讨双时相^(18)F-FDG PET 显像在肿瘤良恶性鉴别中的临床价值。方法 52例单次显像难以鉴别病变性质的患者行双时相全身^(18)F-FDG PET/CT 显像,将显像结果与病理学检查结果对照。结果 43例延迟显像 SUV 升高的患者中有39例经病理检查证实为恶性病变,4例为良性病变;9例延迟显像 SUV 降低的患者中有7例经病理检查证实为良性病变,2例为恶性病变。灵敏度为95.1%,准确性为88.5%,特异性为63.6%,阳性预测值为90.7%,阴性预测值为7/9例。结论双时相^(18)F-FDG PET 对良恶性病变的鉴别具有较高的灵敏度和准确性。

Objective It was realized that static PET imaging might not be accurate at fixed time point after ^18 F-FDG administration. The dual phase ^18 F-FDG PET was employed in this study in order to differentiate malignant from benign lesions. Methods Fifty-two patients with difficulty in interpreting the nature of their lesions at routine imaging underwent delayed whole body ^18F-FDG PET at 2 h post-injection. Visual inspection of PET images and SUV compared with pathological finding were used for evaluation. Results Of 43 cases with increased SUV in delay imaging, 39 were confirmed/nalignant and 4 benign. And 7 of 9 cases with decreased SUV were confirmed benign and 2 malignant. The dual phase PET imaging in this group of patients had sensitivity of 95.1%, specificity 63.6%, accuracy 88.5%, positive predictive value 90.7%, and negative predictive value 7/9. Conclusion In differentiating malignant from benign lesions, dual phase PET was more accurate than single static imaging.