高强度聚焦超声对射频消融后肝癌残余病灶的治疗

Clinical Research on High Intensity Focused Ultrasound Treatment for Residual Hepatic Tumor after Radiofrequency Treatment

目的:探讨HIFU技术治疗原发性肝癌经射频治疗后残余病灶的安全性和临床可行性。方法:对6例经射频治疗后有残余不规则病灶的原发性肝癌患者,在接受部分肋骨切除术后进行HIFU治疗,对6例原发性肝癌患者经射频治疗后影像学检查证实的6个形状不规则残留病灶行HIFU治疗,观察患者生命体征,主要脏器功能,治疗区7～14天行动态增强MRI检查评价HIFU治疗效果。结果:6例患者在HIFU治疗过程中和治疗后48h生命体征平稳,肝、肾功能正常,动态增强MRI检查证实残余病灶均全部灭活,平均随访12.2个月(6～21个月),未出现局部复发和新生病灶。结论:HIFU技术是安全有效的体外适形治疗肝肿瘤的方法。

To explore the clinical efficacy of high intensity focused ultrasound （HIFU） lreatment for residual hepatic tumor after radiofrequency treatment. Methods： Six patients with residual hepatic tumors of different shapes and sizes after radiofrequency treatment received HIFU treatment and partial costectonmy. MRI was used to evaluate the therapeutic effect of HIFU. Seven to fourteen days after HIFU treatment, vital signs and main organ functions were observed. Results： All of the patients tolerated costectomy and HIFU treatment well. The patients vital signs were stable during the treatment and within 48 hours after the treatment. Dynamic： MRI examination showed a complete ablation of the residual tumors in all of the patients. During follow-up, all of the patients survived, disease free, for 6-21 months. Conclusion： HIFU is a safe, effective and noninvasive treatment for hepatic tumors.