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MUC1及同种型MUC1/Y基因mRNA在膀胱癌中的表达及临床意义 被引量：1

Expression and Clinical Significance of Tumor Associated Antigen MUC1 and Its Isoform MUC1/Y mRNA in Bladder Cancer
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摘要 目的:探讨肿瘤相关抗原MUC1及同种型MUC1/Y粘蛋白基因在膀胱癌中mRNA的表达及其临床意义。方法:22例膀胱癌的组织样本(实验组)和10例正常膀胱组织样本(对照组)中提取总RNA,采用逆转录聚合酶链反应(RT-PCR)技术,检测两组样本中MUC1及同种型MUC1/Y粘蛋白基因mRNA表达水平。结果:膀胱癌组织的MUC1mRNA水平较正常膀胱组织显著增高(P<0.01);Ⅲ-Ⅳ期膀胱癌组织的MUC1/YmRNA水平较Ⅰ-Ⅱ期膀胱癌组织显著增高(P<0.01)。结论:MUC1及同种型MUC1/Y粘蛋白基因mRNA表达水平与膀胱癌有关,对膀胱癌的诊断和治疗有临床意义。 To investigate the transcription level and clinical significance of tumor associated antigen MUC1 and its isoform MUC1/Y in human bladder cancer. Methods： The expression of MUC1 and its isoform MUClfY mRNA was examined by RT-PCR in 22 cases of bladder cancer and 10 normal bladder tissues. Results： The mRNA expression level of MUCI and its isoform MUC1/Y in bladder cancer tissues was significantly higher than that in normal bladder tissues （P〈0.01）. Meanwhile, the expression level of MUC1/Y mRNA in bladder cancer tissues of stages Ⅲ-Ⅳ was significantly higher than that of tissues of stages I - I] （P〈0.01）. Conclusion： Detecting transcription levels of MUC1 and its isoform MUC1/Y may be helpful in the diagnosis and immunotherapy of bladder cancer, and it can predict metastasis and invasion.
作者 罗刚 周四维 叶章群 李志坚 黎卫 周华扩 高新
机构地区 中山大学附属第三医院泌尿外科 华中科技大学同济医学院附属同济医院泌尿外科 中山大学附属中山医院泌尿外科
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2007年第19期1089-1091,1096,共4页 Chinese Journal of Clinical Oncology
基金 国家自然科学基金资助(编号:30271300)
关键词 肿瘤相关抗原 MUC1 MUC1/Y基因表达膀胱癌 Tumor associated antigen MUC1,MUC1/Y Gene expression Bladder neoplasm
分类号 R737.14 [医药卫生—肿瘤]
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参考文献13

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二级参考文献21

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中国肿瘤临床
2007年 第19期

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