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CD4^+CD25^+调节性T细胞的研究进展 被引量：4

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摘要 CD4+CD25+调节性T细胞(regulatory T cell,Treg)具有维持自身免疫耐受和调节免疫应答的功能,其功能紊乱或数目下降是导致自身免疫性疾病的重要原因之一。近年来,研究发现Foxp3在调控CD4+CD25+Treg细胞的发育和功能上起着重要作用。本文就CD4+CD25+Treg细胞的免疫抑制机制、Foxp3在其发育和功能上的作用、IL-2和细胞毒性T淋巴细胞相关抗原4(CTLA-4)等对其产生、维持及活化的作用等方面作一综述。
作者 方雪晖 苏虹
机构地区 安徽医科大学流行病与卫生统计学系
出处 《临床输血与检验》 CAS 2007年第4期378-381,共4页 Journal of Clinical Transfusion and Laboratory Medicine
关键词 CD4^+ CD25^+调节性T细胞 FOXP3 IL-2 CTLA-4
分类号 R392.1 [医药卫生—免疫学] R593.2 [医药卫生—内科学]
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参考文献27

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同被引文献42

  • 1裘宇容,杨春莉,李娟,郑磊,王春燕,包杰.SLE患者T细胞亚群及CD4^+CD25^+T细胞的检测及意义[J].热带医学杂志,2006,6(7):765-767. 被引量：4
  • 2周敏,郭雪君,杨敏.支气管哮喘BALB/c小鼠肺组织及肺T细胞中Notch1的表达[J].上海交通大学学报（医学版）,2007,27(2):161-164. 被引量：7
  • 3罗莉,王国春,魏丽.CD4^+ CD25^+ T细胞在系统性红斑狼疮中的表达及意义[J].中国免疫学杂志,2007,23(6):567-569. 被引量：2
  • 4Sakaguchi S. Naturally arising CD4^+ regulator T cells for immunologic self-tolerance and negative control of immune responses [J]. Annu Rev Immunol, 2004, 22:531-62.
  • 5Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus[J]. J Autoimmun, 2003, 21( 3): 273-6.
  • 6Sakaguchi S,Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains(CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases [J]. J Immunol, 1995, 155(3): 1151.
  • 7Hartigan-O'Connor DJ,Poon C,Sinelair E,et al. Human CD4 regulatory T cells express lower levels of the IL-7 receptor alpha chain(CD127),allowing consistent identity cation and sor ting of live cells. J Immunol Methods,2007,319(1-2):41-52.
  • 8Feuerer M,Mill JA,Mathis D,et al. Foxp3+regulatory T cell: differentiation, specification, subphenotypes. Nat J Immunol, 2009,10(7):689-695.
  • 9Kim J K,Klinger M,Benjamin J,et al. Impact of the TCR signal on regulatory T cell home ostasis, function and trafficking. PLoS One,2009,4(8):6580.
  • 10Zhou X,Bailey-Bucktrout S,Jeker LT,et al. Plasticity of CD4 (+)Foxp3(+)T cells. Curr Opin Immunol,2009,21(3):281-285.

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临床输血与检验
2007年 第4期

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